Ontology highlight
ABSTRACT:
SUBMITTER: Sunahara S
PROVIDER: S-EPMC5773584 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Sunahara Satoshi S Watanabe Eizo E Hatano Masahiko M Swanson Paul E PE Oami Takehiko T Fujimura Lisa L Teratake Youichi Y Shimazui Takashi T Lee Chiwei C Oda Shigeto S
Scientific reports 20180118 1
The role of autophagy in the maintenance of renal homeostasis during sepsis is not well understood. We therefore aimed to determine the influence of autophagy on kidney during sepsis using a murine sepsis model, i.e. cecal ligation and puncture (CLP). In CLP treated animals, the number of autolysosomes observed by electron microscopy increased over time. The number of autophagosomes in CLP animals decreased relative sham operated controls at 24 hrs after CLP, indicating that autophagy flux is al ...[more]