Ontology highlight
ABSTRACT:
SUBMITTER: Risso D
PROVIDER: S-EPMC5773593 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Risso Davide D Perraudeau Fanny F Gribkova Svetlana S Dudoit Sandrine S Vert Jean-Philippe JP
Nature communications 20180118 1
Single-cell RNA-sequencing (scRNA-seq) is a powerful high-throughput technique that enables researchers to measure genome-wide transcription levels at the resolution of single cells. Because of the low amount of RNA present in a single cell, some genes may fail to be detected even though they are expressed; these genes are usually referred to as dropouts. Here, we present a general and flexible zero-inflated negative binomial model (ZINB-WaVE), which leads to low-dimensional representations of t ...[more]