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Serum uric acid levels in patients with amyotrophic lateral sclerosis: a meta-analysis.


ABSTRACT: The pathogenic mechanism of ALS remains unclear. However, increasing evidence has indicated that uric acid (UA) may play a protective role in the pathogenesis of ALS. The aim of this study was to evaluate the association between serum UA levels and ALS. A comprehensive literature search in PubMed, Embase, Web of Science, and Cochrane Library was conducted up to 31st August, 2017, using keywords. A random-effects model or fixed-effects model was used to calculate the pooled estimate according to the inter-group heterogeneity. Finally, we indentified 8 case-control and 3 cohort studies. The results indicated that patients with ALS had significant decreased levels of serum UA compared to healthy controls (standardized mean difference (SMD)?=?-0.72, 95% CI [-0.98,-0.46], P?

SUBMITTER: Zhang F 

PROVIDER: S-EPMC5773600 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Serum uric acid levels in patients with amyotrophic lateral sclerosis: a meta-analysis.

Zhang Fan F   Zhang Qin Q   Ke Yaqiong Y   Hao Jianbo J   Lu Ling L   Lu Nannan N   Chen Xiling X  

Scientific reports 20180118 1


The pathogenic mechanism of ALS remains unclear. However, increasing evidence has indicated that uric acid (UA) may play a protective role in the pathogenesis of ALS. The aim of this study was to evaluate the association between serum UA levels and ALS. A comprehensive literature search in PubMed, Embase, Web of Science, and Cochrane Library was conducted up to 31st August, 2017, using keywords. A random-effects model or fixed-effects model was used to calculate the pooled estimate according to  ...[more]

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