Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region.

ABSTRACT: Food allergy is an increasingly important health problem in the world. Several genome-wide association studies (GWAS) focused on European ancestry samples have identified food allergy-specific loci in the HLA class II region. We conducted GWAS of self-reported reactivity with common foods using the data from 11011 Japanese women and identified shrimp and peach allergy-specific loci in the HLA-DR/DQ gene region tagged by rs74995702 (P = 6.30 × 10^-17, OR = 1.91) and rs28359884 (P = 2.3 × 10^-12, OR = 1.80), respectively. After HLA imputation using a Japanese population-specific reference, the most strongly associated haplotype was HLA-DRB1*04:05-HLA-DQB1*04:01 for shrimp allergy (P = 3.92 × 10^-19, OR = 1.99) and HLA-DRB1*09:01-HLA-DQB1*03:03 for peach allergy

SUBMITTER: Khor SS 

PROVIDER: S-EPMC5773682 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature