The signature of liver cancer in immune cells DNA methylation.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5774119 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
The signature of liver cancer in immune cells DNA methylation.
Zhang Yonghong Y Petropoulos Sophie S Liu Jinhua J Cheishvili David D Zhou Rudy R Dymov Sergiy S Li Kang K Li Ning N Szyf Moshe M
Clinical epigenetics 20180118
<h4>Background</h4>The idea that changes to the host immune system are critical for cancer progression was proposed a century ago and recently regained experimental support.<h4>Results</h4>Herein, the hypothesis that hepatocellular carcinoma (HCC) leaves a molecular signature in the host peripheral immune system was tested by profiling DNA methylation in peripheral blood mononuclear cells (PBMC) and T cells from a discovery cohort (<i>n</i> = 69) of healthy controls, chronic hepatitis, and HCC u ...[more]
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