The signature of liver cancer in immune cells DNA methylation.
Ontology highlight
ABSTRACT: Background
The idea that changes to the host immune system are critical for cancer progression was proposed a century ago and recently regained experimental support.Results
Herein, the hypothesis that hepatocellular carcinoma (HCC) leaves a molecular signature in the host peripheral immune system was tested by profiling DNA methylation in peripheral blood mononuclear cells (PBMC) and T cells from a discovery cohort (n = 69) of healthy controls, chronic hepatitis, and HCC using Illumina 450K platform and was validated in two validation sets (n = 80 and n = 48) using pyrosequencing.Conclusions
The study reveals a broad signature of hepatocellular carcinoma in PBMC and T cells DNA methylation which discriminates early HCC stage from chronic hepatitis B and C and healthy controls, intensifies with progression of HCC, and is highly enriched in immune function-related genes such as PD-1, a current cancer immunotherapy target. These data also support the feasibility of using these profiles for early detection of HCC.
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5774119 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
The signature of liver cancer in immune cells DNA methylation.
Zhang Yonghong Y Petropoulos Sophie S Liu Jinhua J Cheishvili David D Zhou Rudy R Dymov Sergiy S Li Kang K Li Ning N Szyf Moshe M
Clinical epigenetics 20180118
<h4>Background</h4>The idea that changes to the host immune system are critical for cancer progression was proposed a century ago and recently regained experimental support.<h4>Results</h4>Herein, the hypothesis that hepatocellular carcinoma (HCC) leaves a molecular signature in the host peripheral immune system was tested by profiling DNA methylation in peripheral blood mononuclear cells (PBMC) and T cells from a discovery cohort (<i>n</i> = 69) of healthy controls, chronic hepatitis, and HCC u ...[more]
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