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Aseptic meningitis in Germany associated with echovirus type 13.

ABSTRACT: BACKGROUND:Echoviruses are the commonest cause of aseptic meningitis. Echovirus type 13 which has not been isolated in Germany over a long period of time was the predominant enterovirus serotype associated with different local outbreaks of aseptic meningitis in Germany in 2000. METHODS:Virus isolation was performed from cerebrospinal fluid and stools. In order to study the genetic relationship of echovirus type 13 isolates, sequence analysis of a part of VP1 (~300 nt) was carried out. Isolates from different geographic regions were compared to each other as well as to elder viruses (prototype strain from 1953, four isolates from 1965-1986). RESULTS:Overall, 55 isolates of echovirus type 13 were obtained from different parts of Germany. It was shown that the new isolated strains have a very high degree of homology on the nucleotide level (> 98%)) but differ significantly from the old strains (76-85%). CONCLUSIONS:a) Rare enterovirus serotypes can cause serious illness.b) The molecular drift has also been shown for other enterovirus serotypes.

SUBMITTER: Diedrich S

PROVIDER: S-EPMC57743 | biostudies-literature | 2001

REPOSITORIES: biostudies-literature

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Aseptic meningitis in Germany associated with echovirus type 13.

Diedrich S S Schreier E E

BMC infectious diseases 20010914

<h4>Background</h4>Echoviruses are the commonest cause of aseptic meningitis. Echovirus type 13 which has not been isolated in Germany over a long period of time was the predominant enterovirus serotype associated with different local outbreaks of aseptic meningitis in Germany in 2000.<h4>Methods</h4>Virus isolation was performed from cerebrospinal fluid and stools. In order to study the genetic relationship of echovirus type 13 isolates, sequence analysis of a part of VP1 (~300 nt) was carried ...[more]

PMID: 11591222

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