Control of species-dependent cortico-motoneuronal connections underlying manual dexterity.
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ABSTRACT:
SUBMITTER: Gu Z
PROVIDER: S-EPMC5774341 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Control of species-dependent cortico-motoneuronal connections underlying manual dexterity.
Gu Zirong Z Kalambogias John J Yoshioka Shin S Han Wenqi W Li Zhuo Z Kawasawa Yuka Imamura YI Pochareddy Sirisha S Li Zhen Z Liu Fuchen F Xu Xuming X Wijeratne H. R. Sagara HRS Ueno Masaki M Blatz Emily E Salomone Joseph J Kumanogoh Atsushi A Rasin Mladen-Roko MR Gebelein Brian B Weirauch Matthew T MT Sestan Nenad N Martin John H JH Yoshida Yutaka Y
Science (New York, N.Y.) 20170701 6349
Superior manual dexterity in higher primates emerged together with the appearance of cortico-motoneuronal (CM) connections during the evolution of the mammalian corticospinal (CS) system. Previously thought to be specific to higher primates, we identified transient CM connections in early postnatal mice, which are eventually eliminated by Sema6D-PlexA1 signaling. <i>PlexA1</i> mutant mice maintain CM connections into adulthood and exhibit superior manual dexterity as compared with that of contro ...[more]
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