Ontology highlight
ABSTRACT:
SUBMITTER: Sivakumar S
PROVIDER: S-EPMC5774855 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Sivakumar Smruthy S Lucas F Anthony San FAS McDowell Tina L TL Lang Wenhua W Xu Li L Fujimoto Junya J Zhang Jianjun J Futreal P Andrew PA Fukuoka Junya J Yatabe Yasushi Y Dubinett Steven M SM Spira Avrum E AE Fowler Jerry J Hawk Ernest T ET Wistuba Ignacio I II Scheet Paul P Kadara Humam H
Cancer research 20170926 22
There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the major lung cancer subtype adenocarcinoma (LUAD). In this study, we performed deep DNA and RNA sequencing analyses of a set of AAH, LUAD, and normal tissues. Somatic <i>BRAF</i> variants were found in AAHs from 5 of 22 (23%) patients, 4 of 5 of whom had matched LUAD with driver <i>EGFR</i> mutations. <i>KRAS</i> mutations were ...[more]