Dataset Information

Indicators of skin barrier integrity among newborns massaged with mustard oil in rural Nepal.

ABSTRACT: OBJECTIVE:The objective of this study was to determine the skin barrier changes during postnatal month 1 among infants receiving routine mustard oil massage in the humid conditions of rural Nepal. STUDY DESIGN:This was an observational study among 500 live-born neonates receiving mustard oil massage. Skin integrity such as erythema, rash, dryness, skin pH, stratum corneum protein concentration and transepidermal water loss was measured on days 1, 3, 7, 14 and 28. RESULTS:Erythema and rash increased (worsened) during weeks 1 and 2, then decreased over weeks 3 and 4. Skin pH (6.1±0.5 to 5.0±0.6) and stratum corneum protein (16.6±7.9 to 13.5±5.9??g?cm-2) decreased. Transepidermal water loss increased from 33.2±23.5 to 43.0±24.5?g?m-2?h-1 at day 28. Skin pH and stratum corneum protein were higher for early versus late premature infants. CONCLUSION:Premature and full-term skin condition was generally poor especially during the first 2 weeks, improving thereafter. Maturational changes were evident.

SUBMITTER: Summers A

PROVIDER: S-EPMC5775032 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Indicators of skin barrier integrity among newborns massaged with mustard oil in rural Nepal.

Summers A A Visscher M O MO Khatry S K SK Sherchand J B JB LeClerq S C SC Katz J J Tielsch J M JM Mullany L C LC

Journal of perinatology : official journal of the California Perinatal Association 20171109 1

<h4>Objective</h4>The objective of this study was to determine the skin barrier changes during postnatal month 1 among infants receiving routine mustard oil massage in the humid conditions of rural Nepal.<h4>Study design</h4>This was an observational study among 500 live-born neonates receiving mustard oil massage. Skin integrity such as erythema, rash, dryness, skin pH, stratum corneum protein concentration and transepidermal water loss was measured on days 1, 3, 7, 14 and 28.<h4>Results</h4>Er ...[more]

PMID: 29120456

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Project description:Tracking progress towards global newborn health targets depends largely on maternal reported data collected through large, nationally representative surveys. We evaluated the validity, across a range of recall period lengths (1 to 24 months post-delivery), of maternal report of birthweight, birth size and length of pregnancy.We compared maternal reports to reference standards of birthweights measured within 72 hours of delivery and gestational age generated from reported first day of the last menstrual period (LMP) prospectively collected as part of a population-based study (n?=?1502). We calculated sensitivity, specificity, area the under the receiver operating curve (AUC) as a measure of individual-level accuracy, and the inflation factor (IF) to quantify population-level bias for each indicator. We assessed if length of recall period modified accuracy by stratifying measurements across time bins and using a modified Poisson regression with robust error variance to estimate the relative risk (RR) of correctly classifying newborns as low birthweight (LBW) or preterm, adjusting for child sex, place of delivery, maternal age, maternal education, parity, and ethnicity.The LBW indicator using maternally reported birthweight in grams had low individual-level accuracy (AUC?=?0.69) and high population-level bias (inflation factor IF?=?0.62). LBW using maternally reported birth size and the preterm birth indicator had lower individual-level accuracy (AUC?=?0.58 and 0.56, respectively) and higher population-level bias (IF?=?0.28 and 0.35, respectively) up to 24 months following birth. Length of recall time did not affect accuracy of LBW indicators. For the preterm birth indicator, accuracy did not change with length of recall up to 20 months after birth and improved slightly beyond 20 months.The use of maternal reports may underestimate and bias indicators for LBW and preterm birth. In settings with high prevalence of LBW and preterm births, these indicators generated from maternal reports may be more vulnerable to misclassification. In populations where an important proportion of births occur at home or where weight is not routinely measured, mothers perhaps place less importance on remembering size at birth. Further work is needed to explore whether these conclusions on the validity of maternal reports hold in similar rural and low-income settings.

Dataset Information

Indicators of skin barrier integrity among newborns massaged with mustard oil in rural Nepal.

Publications

Indicators of skin barrier integrity among newborns massaged with mustard oil in rural Nepal.

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