Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder.
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ABSTRACT:
SUBMITTER: Grabrucker S
PROVIDER: S-EPMC5775238 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder.
Grabrucker Stefanie S Haderspeck Jasmin C JC Sauer Ann Katrin AK Kittelberger Nadine N Asoglu Harun H Abaei Alireza A Rasche Volker V Schön Michael M Boeckers Tobias M TM Grabrucker Andreas M AM
Frontiers in molecular neuroscience 20180115
A number of studies have reported changes in the hemispheric dominance in autism spectrum disorder (ASD) patients on functional, biochemical, and morphological level. Since asymmetry of the brain is also found in many vertebrates, we analyzed whether prenatal zinc deficient (PZD) mice, a mouse model with ASD like behavior, show alterations regarding brain lateralization on molecular and behavioral level. Our results show that hemisphere-specific expression of marker genes is abolished in PZD mic ...[more]
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