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Marine sponge alkaloids as a source of anti-bacterial adjuvants.

ABSTRACT: Novel approaches that do not rely upon developing microbicidal compounds are sorely needed to combat multidrug resistant (MDR) bacteria. The potential of marine secondary metabolites to serve as a source of non-traditional anti-bacterial agents is demonstrated by showing that pyrrole-imidazole alkaloids inhibit biofilm formation and suppress antibiotic resistance.

SUBMITTER: Melander RJ

PROVIDER: S-EPMC5776710 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Marine sponge alkaloids as a source of anti-bacterial adjuvants.

Melander Roberta J RJ Liu Hong-Bing HB Stephens Matthew D MD Bewley Carole A CA Melander Christian C

Bioorganic & medicinal chemistry letters 20161109 24

Novel approaches that do not rely upon developing microbicidal compounds are sorely needed to combat multidrug resistant (MDR) bacteria. The potential of marine secondary metabolites to serve as a source of non-traditional anti-bacterial agents is demonstrated by showing that pyrrole-imidazole alkaloids inhibit biofilm formation and suppress antibiotic resistance. ...[more]

PMID: 27876320

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