Ontology highlight
ABSTRACT:
SUBMITTER: Herkt SC
PROVIDER: S-EPMC5777187 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Herkt Stefanie C SC Kuvardina Olga N ON Herglotz Julia J Schneider Lucas L Meyer Annekarin A Pommerenke Claudia C Salinas-Riester Gabriela G Seifried Erhard E Bonig Halvard H Lausen Jörn J
Haematologica 20171012 1
Hematopoietic differentiation is driven by transcription factors, which orchestrate a finely tuned transcriptional network. At bipotential branching points lineage decisions are made, where key transcription factors initiate cell type-specific gene expression programs. These programs are stabilized by the epigenetic activity of recruited chromatin-modifying cofactors. An example is the association of the transcription factor RUNX1 with protein arginine methyltransferase 6 (PRMT6) at the megakary ...[more]