Ontology highlight
ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC5777230 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Jin Lingtao L Chun Jaemoo J Pan Chaoyun C Kumar Avi A Zhang Guojing G Ha Youna Y Li Dan D Alesi Gina N GN Kang Yibin Y Zhou Lu L Yu Wen-Mei WM Magliocca Kelly R KR Khuri Fadlo R FR Qu Cheng-Kui CK Metallo Christian C Owonikoko Taofeek K TK Kang Sumin S
Molecular cell 20171214 1
Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer, but the development of targeted agents is in its infancy. Here we report that a glutaminolytic enzyme, glutamate dehydrogenase 1 (GDH1), upregulated upon detachment via pleomorphic adenoma gene 1 (PLAG1), provides anti-anoikis and pro-metastatic signals in LKB1-deficient lung cancer. Mechanistically, the GDH1 product α-KG activates CamKK2 by enhancing its substrate AMPK binding, which contributes to energy pr ...[more]