Ontology highlight
ABSTRACT:
SUBMITTER: Wan L
PROVIDER: S-EPMC5777296 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Molecular cell 20180101 2
Sustained energy starvation leads to activation of AMP-activated protein kinase (AMPK), which coordinates energy status with numerous cellular processes including metabolism, protein synthesis, and autophagy. Here, we report that AMPK phosphorylates the histone methyltransferase EZH2 at T311 to disrupt the interaction between EZH2 and SUZ12, another core component of the polycomb repressive complex 2 (PRC2), leading to attenuated PRC2-dependent methylation of histone H3 at Lys27. As such, PRC2 t ...[more]