Ontology highlight
ABSTRACT:
SUBMITTER: Li XL
PROVIDER: S-EPMC5777516 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Li Xiao Ling XL Subramanian Murugan M Jones Matthew F MF Chaudhary Ritu R Singh Deepak K DK Zong Xinying X Gryder Berkley B Sindri Sivasish S Mo Min M Schetter Aaron A Wen Xinyu X Parvathaneni Swetha S Kazandjian Dickran D Jenkins Lisa M LM Tang Wei W Elloumi Fathi F Martindale Jennifer L JL Huarte Maite M Zhu Yuelin Y Robles Ana I AI Frier Susan M SM Rigo Frank F Cam Maggie M Ambs Stefan S Sharma Sudha S Harris Curtis C CC Dasso Mary M Prasanth Kannanganattu V KV Lal Ashish A
Cell reports 20170901 10
Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression. Here, we report the suppression of basal p53 levels by a nuclear, p53-regulated long noncoding RNA that we termed PURPL (p53 upregulated regulator of p53 levels). Targeted depletion of PURPL in colorectal cancer cells results in elevated basal p53 levels and induces growth defects in cell culture and in mouse xen ...[more]