Ontology highlight
ABSTRACT:
SUBMITTER: Lepesheva G
PROVIDER: S-EPMC5777588 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Lepesheva Galina G Christov Plamen P Sulikowski Gary A GA Kim Kwangho K
Tetrahedron letters 20170925 45
The study and development of azole-based CYP51 inhibitors is an active area of research across disciplines of biochemistry, pharmacology and infectious disease. Support of in vitro and in vivo studies require the development of robust asymmetric routes to single enantiomer products of this class of compounds. Herein, we describe a scalable and enantioselective synthesis to VNI and VFV, the two potent inhibitors of protozoan sterol 14α-demethylase (CYP51) that are currently under consideration fo ...[more]