Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-?B signaling.
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ABSTRACT:
SUBMITTER: Deng H
PROVIDER: S-EPMC5777703 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-κB signaling.
Deng Huidan H Kuang Ping P Cui Hengmin H Luo Qin Q Liu Huan H Lu Yujiao Y Fang Jing J Zuo Zhicai Z Deng Junliang J Li Yinglun Y Wang Xun X Zhao Ling L
Oncotarget 20171201 70
In this study, we investigated the roles of reactive oxygen species (ROS) and nuclear factor-κB (NF-κB) signaling in sodium fluoride-induced DNA damage and apoptosis in mouse splenocytes. Intragastric administration of 12, 24 or 48 mg/kg sodium fluoride resulted in a time- and dose-dependent increase in DNA fragmentation and apoptosis in mouse splenocytes on days 21 and 42. High ROS levels correlated with increased levels of phosphorylated IκB kinase and NF-κB p65 and decreased levels of inhibit ...[more]
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