Ontology highlight
ABSTRACT:
SUBMITTER: Mori T
PROVIDER: S-EPMC5778007 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Mori Tomoyuki T Ito Takumi T Liu Shujie S Ando Hideki H Sakamoto Satoshi S Yamaguchi Yuki Y Tokunaga Etsuko E Shibata Norio N Handa Hiroshi H Hakoshima Toshio T
Scientific reports 20180122 1
Thalidomide possesses two optical isomers which have been reported to exhibit different pharmacological and toxicological activities. However, the precise mechanism by which the two isomers exert their different activities remains poorly understood. Here, we present structural and biochemical studies of (S)- and (R)-enantiomers bound to the primary target of thalidomide, cereblon (CRBN). Our biochemical studies employed deuterium-substituted thalidomides to suppress optical isomer conversion, an ...[more]