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Gene annotation bias impedes biomedical research.


ABSTRACT: We found tremendous inequality across gene and protein annotation resources. We observed that this bias leads biomedical researchers to focus on richly annotated genes instead of those with the strongest molecular data. We advocate that researchers reduce these biases by pursuing data-driven hypotheses.

SUBMITTER: Haynes WA 

PROVIDER: S-EPMC5778030 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Gene annotation bias impedes biomedical research.

Haynes Winston A WA   Tomczak Aurelie A   Khatri Purvesh P  

Scientific reports 20180122 1


We found tremendous inequality across gene and protein annotation resources. We observed that this bias leads biomedical researchers to focus on richly annotated genes instead of those with the strongest molecular data. We advocate that researchers reduce these biases by pursuing data-driven hypotheses. ...[more]

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