Ontology highlight
ABSTRACT:
SUBMITTER: Windgassen TA
PROVIDER: S-EPMC5778457 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Windgassen Tricia A TA Wessel Sarah R SR Bhattacharyya Basudeb B Keck James L JL
Nucleic acids research 20180101 2
Multi-protein DNA replication complexes called replisomes perform the essential process of copying cellular genetic information prior to cell division. Under ideal conditions, replisomes dissociate only after the entire genome has been duplicated. However, DNA replication rarely occurs without interruptions that can dislodge replisomes from DNA. Such events produce incompletely replicated chromosomes that, if left unrepaired, prevent the segregation of full genomes to daughter cells. To mitigate ...[more]