Ontology highlight
ABSTRACT:
SUBMITTER: Cencini M
PROVIDER: S-EPMC5778461 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cencini Massimo M Pigolotti Simone S
Nucleic acids research 20180101 2
Transcription factors (TFs) are able to associate to their binding sites on DNA faster than the physical limit posed by diffusion. Such high association rates can be achieved by alternating between three-dimensional diffusion and one-dimensional sliding along the DNA chain, a mechanism-dubbed facilitated diffusion. By studying a collection of TF binding sites of Escherichia coli from the RegulonDB database and of Bacillus subtilis from DBTBS, we reveal a funnel in the binding energy landscape ar ...[more]