Ontology highlight
ABSTRACT:
SUBMITTER: Martins AL
PROVIDER: S-EPMC5778497 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Martins André L AL Walavalkar Ninad M NM Anderson Warren D WD Zang Chongzhi C Guertin Michael J MJ
Nucleic acids research 20180101 2
Coupling molecular biology to high-throughput sequencing has revolutionized the study of biology. Molecular genomics techniques are continually refined to provide higher resolution mapping of nucleic acid interactions and structure. Sequence preferences of enzymes can interfere with the accurate interpretation of these data. We developed seqOutBias to characterize enzymatic sequence bias from experimental data and scale individual sequence reads to correct intrinsic enzymatic sequence biases. Se ...[more]