Ontology highlight
ABSTRACT:
SUBMITTER: Chen K
PROVIDER: S-EPMC5779224 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Chen Keyu K Li Jianchao J Wang Chao C Wei Zhiyi Z Zhang Mingjie M
eLife 20170825
Ankyrins together with their spectrin partners are the master organizers of micron-scale membrane domains in diverse tissues. The 24 ankyrin (ANK) repeats of ankyrins bind to numerous membrane proteins, linking them to spectrin-based cytoskeletons at specific membrane microdomains. The accessibility of the target binding groove of ANK repeats must be regulated to achieve spatially defined functions of ankyrins/target complexes in different tissues, though little is known in this regard. Here we ...[more]