Modeling specific action potentials in the human atria based on a minimal single-cell model.
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ABSTRACT:
SUBMITTER: Richter Y
PROVIDER: S-EPMC5779667 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Modeling specific action potentials in the human atria based on a minimal single-cell model.
Richter Yvonne Y Lind Pedro G PG Maass Philipp P
PloS one 20180123 1
We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale. By applying a nonlinear optimization procedure, a best combination of the respective time scales is determined, which allows one to reproduce specific action potentials with a give ...[more]
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