Hypertonic saline resuscitation after emergent laparotomy and temporary abdominal closure.

ABSTRACT:

Background

Our objective was to establish the safety of 3% hypertonic saline (HTS) resuscitation for trauma and acute care surgery patients undergoing emergent laparotomy and temporary abdominal closure (TAC) with the hypothesis that HTS administration would be associated with hyperosmolar hypercholoremic acidosis, lower resuscitation volumes, and higher fascial closure rates, without adversely affecting renal function.

Methods

We performed a retrospective cohort analysis of 189 trauma and acute care surgery patients who underwent emergent laparotomy and TAC, comparing patients with normal baseline renal function who received 3% HTS at 30 mL/h (n = 36) to patients with standard resuscitation (n = 153) by baseline characteristics, resuscitation parameters, and outcomes includ

SUBMITTER: Loftus TJ 

PROVIDER: S-EPMC5780232 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature