Ontology highlight
ABSTRACT:
SUBMITTER: Sclafani F
PROVIDER: S-EPMC5780472 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Sclafani Francesco F Chau Ian I Cunningham David D Hahne Jens C JC Vlachogiannis George G Eltahir Zakaria Z Lampis Andrea A Braconi Chiara C Kalaitzaki Eleftheria E De Castro David Gonzalez DG Wotherspoon Andrew A Capdevila Jaume J Glimelius Bengt B Tarazona Noelia N Begum Ruwaida R Lote Hazel H Hulkki Wilson Sanna S Mentrasti Giulia G Brown Gina G Tait Diana D Oates Jacqueline J Valeri Nicola N
Scientific reports 20180123 1
There are limited data on circulating, cell-free, tumour (ct)DNA analysis in locally advanced rectal cancer (LARC). Digital droplet (dd)PCR was used to investigate KRAS/BRAF mutations in ctDNA from baseline blood samples of 97 LARC patients who were treated with CAPOX followed by chemoradiotherapy, surgery and adjuvant CAPOX ± cetuximab in a randomised phase II trial. KRAS mutation in G12D, G12V or G13D was detected in the ctDNA of 43% and 35% of patients with tumours that were mutant and wild-t ...[more]