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Plasmid-Encoded Transferable mecB-Mediated Methicillin Resistance in Staphylococcus aureus.

ABSTRACT: During cefoxitin-based nasal screening, phenotypically categorized methicillin-resistant Staphylococcus aureus (MRSA) was isolated and tested negative for the presence of the mecA and mecC genes as well as for the SCCmec-orfX junction region. The isolate was found to carry a mecB gene previously described for Macrococcus caseolyticus but not for staphylococcal species. The gene is flanked by β-lactam regulatory genes similar to mecR, mecI, and blaZ and is part of an 84.6-kb multidrug-resistance plasmid that harbors genes encoding additional resistances to aminoglycosides (aacA-aphD, aphA, and aadK) as well as macrolides (ermB) and tetracyclines (tetS). This further plasmidborne β-lactam resistance mechanism harbors the putative risk of acceleration or reacceleration of MRSA spread, resulting in broad ineffectiveness of β-lactams as a main therapeutic application against staphylococcal infections.

SUBMITTER: Becker K 

PROVIDER: S-EPMC5782906 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Plasmid-Encoded Transferable mecB-Mediated Methicillin Resistance in Staphylococcus aureus.

Becker Karsten K   van Alen Sarah S   Idelevich Evgeny A EA   Schleimer Nina N   Seggewiß Jochen J   Mellmann Alexander A   Kaspar Ursula U   Peters Georg G  

Emerging infectious diseases 20180201 2

During cefoxitin-based nasal screening, phenotypically categorized methicillin-resistant Staphylococcus aureus (MRSA) was isolated and tested negative for the presence of the mecA and mecC genes as well as for the SCCmec-orfX junction region. The isolate was found to carry a mecB gene previously described for Macrococcus caseolyticus but not for staphylococcal species. The gene is flanked by β-lactam regulatory genes similar to mecR, mecI, and blaZ and is part of an 84.6-kb multidrug-resistance  ...[more]

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