Ontology highlight
ABSTRACT:
SUBMITTER: Khan MW
PROVIDER: S-EPMC5783191 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Khan Mohammad W MW Saadalla Abdulrahman A Ewida Ahmed H AH Al-Katranji Khalid K Al-Saoudi Ghadier G Giaccone Zachary T ZT Gounari Fotini F Zhang Ming M Frank David A DA Khazaie Khashayarsha K
Cancer immunology, immunotherapy : CII 20170905 1
The transcription factor signal activator and transducer or transcription (STAT3), which regulates genes controlling proliferation, survival, and invasion, is activated inappropriately in many human cancers, including breast cancer. Activation of STAT3 can lead to both malignant cellular behavior and suppression of immune cell function in the tumor microenvironment. Through a chemical-biology screen, pyrimethamine (PYR), an FDA approved anti-microbial drug, was identified as an inhibitor of STAT ...[more]