Ontology highlight
ABSTRACT:
SUBMITTER: Arruabarrena-Aristorena A
PROVIDER: S-EPMC5783676 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Arruabarrena-Aristorena Amaia A Zabala-Letona Amaia A Carracedo Arkaitz A
Science advances 20180124 1
The study of metabolism has provided remarkable information about the biological basis and therapeutic weaknesses of cancer cells. Classic biochemistry established the importance of metabolic alterations in tumor biology and revealed the importance of various metabolite families to the tumorigenic process. We have evidence of the central role of polyamines, small polycatonic metabolites, in cell proliferation and cancer growth from these studies. However, how cancer cells activate this metabolic ...[more]