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Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction.

ABSTRACT: OBJECTIVE:To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). METHODS:A primary cohort (N?=?12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N?=?22). RESULTS:After surgery-induced weight loss, Minnesota Living with Heart Failure questionnaire scores, cardiac mass, and liver fat decreased (P?

SUBMITTER: Mikhalkova D

PROVIDER: S-EPMC5783730 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction.

Mikhalkova Deana D Holman Sujata R SR Jiang Hui H Saghir Mohammed M Novak Eric E Coggan Andrew R AR O'Connor Robert R Bashir Adil A Jamal Ali A Ory Daniel S DS Schaffer Jean E JE Eagon J Christopher JC Peterson Linda R LR

Obesity (Silver Spring, Md.) 20171215 2

<h4>Objective</h4>To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF).<h4>Methods</h4>A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary co ...[more]

PMID: 29243396

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