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Body Mass Index and Subjective Social Status: The Coronary Artery Risk Development in Young Adults Study.

ABSTRACT: OBJECTIVE:Subjective social status (SSS), or perceived social status, may explain, in part, the relationship between socioeconomic status (SES) and obesity. The objective of this study was to test whether SSS mediates the relationship between two indicators of SES (income and education) and body mass index (BMI). METHODS:A cross-sectional, structural equation path analysis was applied to the Coronary Artery Risk Development in Young Adults (CARDIA) study (n?=?2,624). The analysis tested whether SSS (MacArthur scale), education, and income were associated with BMI at the year 20 examination (adjusting for sex, age, and race), and it was hypothesized that the associations of education and income with BMI would be at least partly mediated by SSS. RESULTS:SSS had a significant direct effect on BMI (-0.21, P?=?0.018). Education had a significant direct relationship with SSS (0.11, P?

SUBMITTER: Dhurandhar EJ

PROVIDER: S-EPMC5783753 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Body Mass Index and Subjective Social Status: The Coronary Artery Risk Development in Young Adults Study.

Dhurandhar Emily J EJ Pavela Gregory G Kaiser Kathryn A KA Dutton Gareth R GR Fontaine Kevin R KR Kim Daniel D Shikany James M JM Allison David B DB Lewis Cora E CE

Obesity (Silver Spring, Md.) 20171227 2

<h4>Objective</h4>Subjective social status (SSS), or perceived social status, may explain, in part, the relationship between socioeconomic status (SES) and obesity. The objective of this study was to test whether SSS mediates the relationship between two indicators of SES (income and education) and body mass index (BMI).<h4>Methods</h4>A cross-sectional, structural equation path analysis was applied to the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 2,624). The analysis ...[more]

PMID: 29280341

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Project description:BACKGROUND:Identifying potentially modifiable risk factors is critically important for reducing the burden of chronic kidney disease. We sought to examine the association of body mass index (BMI) with kidney function decline in a cohort of young adults with preserved glomerular filtration at baseline. STUDY DESIGN:Longitudinal cohort. SETTING & PARTICIPANTS:2,839 black and white young adults with cystatin C-based estimated glomerular filtration rate (eGFRcys)>90mL/min/1.73m(2) taking part in the year-10 examination (in 1995-1996) of the Coronary Artery Risk Development in Young Adults (CARDIA) Study. PREDICTOR:BMI, categorized as 18.5-24.9 (reference), 25.0-29.9, 30.0-39.9, and ?40.0kg/m(2). OUTCOMES:Trajectory of kidney function decline, rapid decline (>3% per year), and incident eGFRcys <60mL/min/1.73m(2) over 10 years of follow-up. MEASUREMENTS:GFRcys estimated from the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation for calibrated cystatin C at CARDIA years 10, 15, and 20. RESULTS:At year 10, participants had a mean age of 35.1 years, median eGFRcys of 114mL/min/1.73m(2), and 24.5% had BMI?30.0kg/m(2). After age 30 years, average eGFRcys was progressively lower with each increment in BMI after adjustment for baseline age, race, sex, hyperlipidemia, smoking status, and physical activity. Higher BMI category was associated with successively higher odds of rapid decline (for 25.0-29.9, 30.0-39.9, and ?40.0kg/m(2), adjusted ORs were 1.50 [95% CI, 1.21-1.87], 2.01 [95% CI, 1.57-2.87], and 2.57 [95% CI, 1.67-3.94], respectively). 18 participants (0.6%) had incident eGFRcys<60mL/min/1.73m(2). In unadjusted analysis, higher BMI category was associated with incident eGFRcys<60mL/min/1.73m(2) (for 25.0-29.9, 30.0-39.9, and ?40.0kg/m(2), ORs were 5.17 [95% CI, 1.10-25.38], 7.44 [95% CI, 1.54-35.95], and 5.55 [95% CI, 0.50-61.81], respectively); adjusted associations were no longer significant. LIMITATIONS:Inability to describe kidney function before differences by BMI category were already evident. Absence of data for measured GFR or GFR estimated from serum creatinine level. CONCLUSIONS:Higher BMI categories are associated with greater declines in kidney function in a cohort of young adults with preserved GFR at baseline. Clinicians should vigilantly monitor overweight and obese patients for evidence of early kidney function decline.

Dataset Information

Body Mass Index and Subjective Social Status: The Coronary Artery Risk Development in Young Adults Study.

Publications

Body Mass Index and Subjective Social Status: The Coronary Artery Risk Development in Young Adults Study.

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