Ontology highlight
ABSTRACT:
SUBMITTER: Samanta S
PROVIDER: S-EPMC5784260 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Samanta S S Sun H H Goel H L HL Pursell B B Chang C C Khan A A Greiner D L DL Cao S S Lim E E Shultz L D LD Mercurio A M AM
Oncogene 20150518 9
IMP3 (insulin-like growth factor-2 mRNA binding protein 3) is an oncofetal protein whose expression is prognostic for poor outcome in several cancers. Although IMP3 is expressed preferentially in triple-negative breast cancer (TNBC), its function is poorly understood. We observed that IMP3 expression is significantly higher in tumor initiating than in non-tumor initiating breast cancer cells and we demonstrate that IMP3 contributes to self-renewal and tumor initiation, properties associated with ...[more]