Ontology highlight
ABSTRACT:
SUBMITTER: Shi B
PROVIDER: S-EPMC5785033 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Shi Baolu B Xue Jiangyang J Zhou Jian J Kasowitz Seth D SD Zhang Yuanwei Y Liang Guanxiang G Guan Yongjuan Y Shi Qinghua Q Liu Mingxi M Sha Jiahao J Huang Xiaoyan X Wang P Jeremy PJ
PLoS genetics 20180112 1
The microrchidia (MORC) family proteins are chromatin-remodelling factors and function in diverse biological processes such as DNA damage response and transposon silencing. Here, we report that mouse Morc2b encodes a functional germ cell-specific member of the MORC protein family. Morc2b arose specifically in the rodent lineage through retrotransposition of Morc2a during evolution. Inactivation of Morc2b leads to meiotic arrest and sterility in both sexes. Morc2b-deficient spermatocytes and oocy ...[more]