Ontology highlight
ABSTRACT:
SUBMITTER: Pan DC
PROVIDER: S-EPMC5785499 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Pan Daniel C DC Myerson Jacob W JW Brenner Jacob S JS Patel Priyal N PN Anselmo Aaron C AC Mitragotri Samir S Muzykantov Vladimir V
Scientific reports 20180125 1
Attachment of nanoparticles (NPs) to the surface of carrier red blood cells (RBCs) profoundly alters their interactions with the host organism, decelerating NP clearance from the bloodstream while enabling NP transfer from the RBC surface to the vascular cells. These changes in pharmacokinetics of NPs imposed by carrier RBCs are favorable for many drug delivery purposes. On the other hand, understanding effects of NPs on the carrier RBCs is vital for successful translation of this novel drug del ...[more]