Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages.
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ABSTRACT:
SUBMITTER: Latroche C
PROVIDER: S-EPMC5785732 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages.
Latroche Claire C Weiss-Gayet Michèle M Muller Laurent L Gitiaux Cyril C Leblanc Pascal P Liot Sophie S Ben-Larbi Sabrina S Abou-Khalil Rana R Verger Nicolas N Bardot Paul P Magnan Mélanie M Chrétien Fabrice F Mounier Rémi R Germain Stéphane S Chazaud Bénédicte B
Stem cell reports 20171130 6
In skeletal muscle, new functions for vessels have recently emerged beyond oxygen and nutrient supply, through the interactions that vascular cells establish with muscle stem cells. Here, we demonstrate in human and mouse that endothelial cells (ECs) and myogenic progenitor cells (MPCs) interacted together to couple myogenesis and angiogenesis in vitro and in vivo during skeletal muscle regeneration. Kinetics of gene expression of ECs and MPCs sorted at different time points of regeneration iden ...[more]
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