Ontology highlight
ABSTRACT:
SUBMITTER: Infante JR
PROVIDER: S-EPMC5785735 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Infante Jeffrey R JR Korn Ronald L RL Rosen Lee S LS LoRusso Patricia P Dychter Samuel S SS Zhu Joy J Maneval Daniel C DC Jiang Ping P Shepard H Michael HM Frost Gregory G Von Hoff Daniel D DD Borad Mitesh J MJ Ramanathan Ramesh K RK
British journal of cancer 20170926 2
<h4>Background</h4>Hyaluronan accumulation in tumour stroma is associated with reduced survival in preclinical cancer models. PEGPH20 degrades hyaluronan to facilitate tumour access for cancer therapies. Our objective was to assess safety and antitumour activity of PEGPH20 in patients with advanced solid tumours.<h4>Methods</h4>In HALO-109-101 (N=14), PEGPH20 was administered intravenously once or twice weekly (0.5 or 50 μg kg<sup>-1</sup>) or once every 3 weeks (0.5-1.5 μg kg<sup>-1</sup>). In ...[more]