Ultrasonography and magnetic resonance imaging changes in patients with polymyalgia rheumatica treated by tocilizumab.

ABSTRACT: BACKGROUND:This study assessed inflammatory changes using ultrasound (US) and magnetic resonance imaging (MRI) in patients taking tocilizumab for polymyalgia rheumatica (PMR). METHODS:Eighteen patients were included in the prospective open-label TENOR study and received three tocilizumab infusions, without corticosteroids. B-mode and power Doppler US and MRI (T1 and T2-short time inversion recuperation weighted sequences) of the hips and shoulders were performed at weeks 0, 2, and 12. Subacromial, trochanteric, and iliopsoas bursitis and intraarticular glenohumeral and coxofemoral effusions/synovitis were scored from 0 to 3. Changes over time and US-MRI correlations were evaluated. RESULTS:At baseline, the proportions of shoulders and hips with bursitis were 93 and 100% by MRI and 61 and 1

SUBMITTER: Huwart A 

PROVIDER: S-EPMC5785834 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature