Ontology highlight
ABSTRACT:
SUBMITTER: Chung JH
PROVIDER: S-EPMC5785960 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Chung Ji Hyun JH Jung Hae Rim HR Jung Ah Ra AR Lee Young Chan YC Kong Moonkyoo M Lee Ju-Seog JS Eun Young-Gyu YG
Scientific reports 20180126 1
SOX2 copy number and mRNA expression were analysed to examine the clinical significance of SOX2 activation in HNSCC. Gene expression signatures reflecting SOX2 activation were identified in an HNSCC cohort. Patients with HNSCC were classified into two subgroups according to the gene expression signature: SOX2-high and SOX2-low. The clinical significance of SOX2 activation was further validated in two independent cohorts. Moreover, clinical significance of SOX2 activation in response to radiother ...[more]