Ontology highlight
ABSTRACT:
SUBMITTER: Evangelidis T
PROVIDER: S-EPMC5786013 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nature communications 20180126 1
Automated methods for NMR structure determination of proteins are continuously becoming more robust. However, current methods addressing larger, more complex targets rely on analyzing 6-10 complementary spectra, suggesting the need for alternative approaches. Here, we describe 4D-CHAINS/autoNOE-Rosetta, a complete pipeline for NOE-driven structure determination of medium- to larger-sized proteins. The 4D-CHAINS algorithm analyzes two 4D spectra recorded using a single, fully protonated protein s ...[more]