Transcription-Associated Compositional Skews in Drosophila Genes.

ABSTRACT: In many organisms, local deviations from Chargaff's second parity rule are observed around replication and transcription start sites and within intron sequences. Here, we use expression data as well as a whole-genome data set of nearly 200 haplotypes to investigate such compositional skews in Drosophila melanogaster genes. We find a positive correlation between compositional skew and gene expression, comparable in strength to similar correlations between expression levels and genome-wide sequence features. This correlation is relatively stronger for germline, compared with somatic expression, consistent with the process of transcription-associated mutation bias. We also inferred mutation rates from alleles segregating at low frequencies in short introns, and show that, whereas the overall

SUBMITTER: Bergman J 

PROVIDER: S-EPMC5786239 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature