Ontology highlight
ABSTRACT:
SUBMITTER: Ge C
PROVIDER: S-EPMC5786553 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Ge Chengfeng C Chen Haiqin H Mei Tiantian T Tang Xin X Chang Lulu L Gu Zhennan Z Zhang Hao H Chen Wei W Chen Yong Q YQ
Frontiers in bioengineering and biotechnology 20180122
In the industrial oleaginous fungus <i>Mortierella alpin</i>a, the arachidonic acid (AA; C20:4; ω-6) fraction can reach 50% of the total fatty acids (TFAs) <i>in vivo</i>. However, the eicosapentaenoic acid (EPA; C20:5; ω-3) fraction is less than 3% when this fungus is cultivated at a low temperature (12°C). Omega-3 fatty acid desaturase is a key enzyme in ω-3 long-chain polyunsaturated fatty acids biosynthesis pathways. To enhance EPA production, we transformed the ω-3 fatty acid desaturase (Pa ...[more]