Neutrophil Extracellular Traps in Plasma from Dogs with Immune-mediated Hemolytic Anemia.

ABSTRACT:

Background

Neutrophil extracellular traps (NETs) are part of the innate immune response and are essential in local pathogen control, but are associated with pathological inflammation, organ damage, autoimmunity, and thrombosis. Immune-mediated hemolytic anemia (IMHA) is a pro-inflammatory, prothrombotic disease associated with high mortality.

Hypothesis/objectives

Neutrophil extracellular traps (NETs) are a feature of the inflammatory process in dogs with IMHA. The objective of the study was to evaluate plasma from dogs with IMHA for the presence of 2 indirect markers and 1 direct marker of NETs.

Animals

Healthy client-owned dogs (56) and hospitalized dogs with IMHA (n = 35).

Methods

Prospective study. Plasma samples for all dogs were evaluated for cell-free DN

SUBMITTER: Lawson C 

PROVIDER: S-EPMC5787156 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature