Dataset Information

Association of thyroid nodules with adiposity: a community-based cross-sectional study in China.

ABSTRACT:

Background

The association between thyroid nodules and adiposity remains controversial. We performed a cross-sectional, community-based study to examine whether thyroid nodules are associated with overweight and obesity, as defined with body mass index (BMI) and waist circumference.

Methods

The study included 1482 subjects (?20 years of age; residing in Nanjing, China) receiving questionnaire interview, anthropometric measurements, laboratory tests and thyroid ultrasonography in 2009-2010. Overweight and obesity were defined as BMI ?24 and ?28 kg/m², respectively. Central obesity was defined as waist circumference at ?90 cm in men and ?80 cm in women. A sensitivity analysis was conducted using the American Diabetes Association (ADA) criteria for overweight and obesity (BMI???23 and ?25 kg/m²).

Results

Thyroid nodules were identified in 12.6% of the subjects. A greater proportion of the subjects with thyroid nodules had a BMI at ?24 kg/m² (51.9% vs. 40.5% in those without thyroid nodules, P?= 0.003) and central obesity (43.3% vs. 24.2%, P 2 (OR 1.61, 95%CI 1.01-2.54), as well as BMI ?25 kg/m² (OR 1.95, 95%CI 1.14-3.34), was significantly associated with higher risk of thyroid nodules among women. Using the ADA criteria, overweight and obesity were associated with thyroid nodules (OR 5.59, 95%CI 1.39-22.51 and 5.15, 95%CI 1.30-20.37) in thyroid-stimulating hormone (TSH) >?4.2 mIU/L subgroup. Central obesity correlated with higher risk of thyroid nodules regardless of age (?4.2 mIU/L (OR 3.05, 95%CI 1.01-9.22), and urine iodine ?200 µg/L (OR 1.79, 95%CI 1.14-2.81).

Conclusion

Waist circumference is superior to BMI for assessing risk of thyroid nodules in Chinese subjects.

SUBMITTER: Song B

PROVIDER: S-EPMC5787304 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Publications

Association of thyroid nodules with adiposity: a community-based cross-sectional study in China.

Song Bin B Zuo Zhihua Z Tan Juan J Guo Jianjin J Teng Weiping W Lu Yibing Y Liu Chao C

BMC endocrine disorders 20180127 1

<h4>Background</h4>The association between thyroid nodules and adiposity remains controversial. We performed a cross-sectional, community-based study to examine whether thyroid nodules are associated with overweight and obesity, as defined with body mass index (BMI) and waist circumference.<h4>Methods</h4>The study included 1482 subjects (≥20 years of age; residing in Nanjing, China) receiving questionnaire interview, anthropometric measurements, laboratory tests and thyroid ultrasonography in 2 ...[more]

PMID: 29374470

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Project description:BackgroundThere is no clear conclusion on the relationship between thyroid disease and obesity and lifestyle factors such as smoking and drinking. In this study, we analysed the association of body mass index (BMI), smoking and drinking with subclinical hypothyroidism (SHO) and thyroid nodules (TNs) with the results of a cross-sectional survey of urban residents in central China and discussed the potential mechanism linking these predictive factors and the two diseases.MethodsThis study included 1279 participants who were recruited from a Chinese community in 2011 and 2012. A questionnaire, laboratory examination and ultrasound diagnosis were conducted on these participants. Binary logistic regression analysis was used to analyse these factors.ResultsOverweight (BMI ≥ 25 kg/m2) was closely related to SHO and TNs in univariate and multivariate logistic regression analyses. Smoking had a protective effect on SHO and TNs, while drinking had a protective effect on TNs in univariate logistic regression and multivariate logistic regression with some covariates, but there was no significant difference between smoking and drinking and the two kinds of thyroid diseases in multivariate logistic regression analysis with all the covariates. In subgroup analysis, BMI ≥ 25 kg/m2 was significantly associated with SHO in people with positive thyroid antibodies (odds ratio (OR) = 2.221, 95 % confidence interval (CI): 1.168-4.184, P = 0.015) and smokers (OR = 2.179, 95 % CI: 1.041-4.561, P = 0.039). BMI ≥ 25 kg/m2 was significantly associated with TNs in people over 60 years old (OR = 2.069, 95 % CI: 1.149-3.724, P = 0.015) and drinkers (OR = 3.065, 95 % CI: 1.413-6.648, P = 0.005). Drinking alcohol had a protective effect on TNs in smokers (OR = 0.456, 95 % CI: 0.240-0.865, P = 0.016) and people with BMI ≥ 25 kg/m2 (OR = 0.467, 95 % CI: 0.236-0.925, P = 0.029). No significant association was found between smoking and the two thyroid diseases in different subgroups.ConclusionsObesity is a risk factor for both TNs and SHO, especially in elderly individuals and people with positive thyroid autoantibodies. Obesity and metabolic syndrome may be more associated with TNs than SHO. Smoking may have a protective effect on thyroid disease, while drinking may have a protective effect only on TNs.

Dataset Information

Association of thyroid nodules with adiposity: a community-based cross-sectional study in China.

Background

Methods

Results

Conclusion

Publications

Association of thyroid nodules with adiposity: a community-based cross-sectional study in China.

Similar Datasets

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