Ontology highlight
ABSTRACT:
SUBMITTER: Provencio M
PROVIDER: S-EPMC5787483 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Provencio Mariano M Torrente María M Calvo Virginia V Pérez-Callejo David D Gutiérrez Lourdes L Franco Fernando F Pérez-Barrios Clara C Barquín Miguel M Royuela Ana A García-García Francisco F Bueno Coralia C Garcia-Grande Aranzazu A Camps Carlos C Massuti Bartomeu B Sotomayor Eduardo E Romero Atocha A
Oncotarget 20171116 1
<h4>Background</h4>Circulating tumor DNA (ctDNA) levels correlate well with tumor bulk. In this paper we aim to estimate the prognostic value of the dynamic quantification of ctDNA levels.<h4>Materials and methods</h4>A total of 251 serial plasma samples from 41 non-small-cell lung cancer patients who carried an activating EGFR mutation were analysed by digital PCR. For survival analysis, ctDNA levels were computed as a time-dependent covariate.<h4>Results</h4>Dynamic ctDNA measurements had prog ...[more]