Ontology highlight
ABSTRACT:
SUBMITTER: Park JY
PROVIDER: S-EPMC5787494 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Park Ji Young JY Jeong Ae Lee AL Joo Hyun Jeong HJ Han Sora S Kim So-Hyun SH Kim Hye-Youn HY Lim Jong-Seok JS Lee Myeong-Sok MS Choi Hyung-Kyoon HK Yang Young Y
Oncotarget 20171207 1
Circulating tumor cells (CTCs) are essential for the establishment of distant metastasis. Numerous studies have characterized CTCs as metastatic precursors; however, the molecular nature of CTCs has not been completely revealed yet due to the low number of CTCs in the blood stream. As an alternative approach, we developed a long-term suspension cell culture model using human breast cancer cell lines to mimic CTCs. We found that more than 40 passaged suspension cells acquired the ability to enhan ...[more]