Ontology highlight
ABSTRACT:
SUBMITTER: Ter Horst R
PROVIDER: S-EPMC5787854 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ter Horst Rob R Jaeger Martin M Smeekens Sanne P SP Oosting Marije M Swertz Morris A MA Li Yang Y Kumar Vinod V Diavatopoulos Dimitri A DA Jansen Anne F M AFM Lemmers Heidi H Toenhake-Dijkstra Helga H van Herwaarden Antonius E AE Janssen Matthijs M van der Molen Renate G RG Joosten Irma I Sweep Fred C G J FCGJ Smit Johannes W JW Netea-Maier Romana T RT Koenders Mieke M J F MMJF Xavier Ramnik J RJ van der Meer Jos W M JWM Dinarello Charles A CA Pavelka Norman N Wijmenga Cisca C Notebaart Richard A RA Joosten Leo A B LAB Netea Mihai G MG
Cell 20161101 4
Differences in susceptibility to immune-mediated diseases are determined by variability in immune responses. In three studies within the Human Functional Genomics Project, we assessed the effect of environmental and non-genetic host factors of the genetic make-up of the host and of the intestinal microbiome on the cytokine responses in humans. We analyzed the association of these factors with circulating mediators and with six cytokines after stimulation with 19 bacterial, fungal, viral, and non ...[more]