A single, continuous metric to define tiered serum neutralization potency against HIV.
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ABSTRACT:
SUBMITTER: Hraber P
PROVIDER: S-EPMC5788501 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
A single, continuous metric to define tiered serum neutralization potency against HIV.
Hraber Peter P Korber Bette B Wagh Kshitij K Montefiori David D Roederer Mario M
eLife 20180119
HIV-1 Envelope (Env) variants are grouped into tiers by their neutralization-sensitivity phenotype. This helped to recognize that tier 1 neutralization responses can be elicited readily, but do not protect against new infections. Tier 3 viruses are the least sensitive to neutralization. Because most circulating viruses are tier 2, vaccines that elicit neutralization responses against them are needed. While tier classification is widely used for viruses, a way to rate serum or antibody neutraliza ...[more]
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