Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5788502 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Liu Yuchen Y Li Jianfa J Chen Zhicong Z Huang Weiren W Cai Zhiming Z
eLife 20180110
Natural signaling circuits could be rewired to reprogram cells with pre-determined procedures. However, it is difficult to link cellular signals at will. Here, we describe signal-connectors<i>-</i>a series of RNA devices<i>-</i>that connect one signal to another signal at the translational level. We use them to either repress or enhance the translation of target genes in response to signals. Application of these devices allows us to construct various logic gates and to incorporate feedback loops ...[more]