Ontology highlight
ABSTRACT:
SUBMITTER: MacPherson A
PROVIDER: S-EPMC5788537 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
MacPherson Ailene A Otto Sarah P SP Nuismer Scott L SL
Genetics 20171209 2
Genome-wide association studies are widely used to identify "disease genes" conferring resistance/susceptibility to infectious diseases. Using a combination of mathematical models and simulations, we demonstrate that genetic interactions between hosts and parasites [genotype-by-genotype (G × G) interactions] can drastically affect the results of these association scans and hamper our ability to detect genetic variation in susceptibility. When hosts and parasites coevolve, these G × G interaction ...[more]