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Design, Bioactivity and structure-activity of 3-Arylpropionate Derivatives as Potential High-Efficient Acaricides against Psoroptes Cuniculi.


ABSTRACT: A series of 3-aryl propionic esters and their analogues were designed and evaluated for acaricidal activity in vitro against Psoroptes cuniculi, a mange mite. The structure-activity relationship (SAR) was also discussed. The results showed that 6 compounds possessed the excellent activity (LC50?=?0.17-0.24?mM, LT50?=?1.5-2.9?h), superior to ivermectin (LC50?=?0.28?mM, LT50?=?8.9?h) (P?

SUBMITTER: Chen D 

PROVIDER: S-EPMC5788918 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Design, Bioactivity and structure-activity of 3-Arylpropionate Derivatives as Potential High-Efficient Acaricides against Psoroptes Cuniculi.

Chen Dongdong D   Tian Ye Y   Xu Mingxuan M   Wang Xinyuan X   Li Ding D   Miao Fang F   Yang Xinjuan X   Zhou Le L  

Scientific reports 20180129 1


A series of 3-aryl propionic esters and their analogues were designed and evaluated for acaricidal activity in vitro against Psoroptes cuniculi, a mange mite. The structure-activity relationship (SAR) was also discussed. The results showed that 6 compounds possessed the excellent activity (LC<sub>50</sub> = 0.17-0.24 mM, LT<sub>50</sub> = 1.5-2.9 h), superior to ivermectin (LC<sub>50</sub> = 0.28 mM, LT<sub>50</sub> = 8.9 h) (P < 0.05), a standard drug. Furthermore, 7 compounds showed the good a  ...[more]

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