Ontology highlight
ABSTRACT:
SUBMITTER: Chen D
PROVIDER: S-EPMC5788918 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Chen Dongdong D Tian Ye Y Xu Mingxuan M Wang Xinyuan X Li Ding D Miao Fang F Yang Xinjuan X Zhou Le L
Scientific reports 20180129 1
A series of 3-aryl propionic esters and their analogues were designed and evaluated for acaricidal activity in vitro against Psoroptes cuniculi, a mange mite. The structure-activity relationship (SAR) was also discussed. The results showed that 6 compounds possessed the excellent activity (LC<sub>50</sub> = 0.17-0.24 mM, LT<sub>50</sub> = 1.5-2.9 h), superior to ivermectin (LC<sub>50</sub> = 0.28 mM, LT<sub>50</sub> = 8.9 h) (P < 0.05), a standard drug. Furthermore, 7 compounds showed the good a ...[more]